Invention Grant
- Patent Title: Modulation of γδ T cells
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Application No.: US14916986Application Date: 2014-09-04
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Publication No.: US10759863B2Publication Date: 2020-09-01
- Inventor: Carl F. Ware , John R. Sedy
- Applicant: Sanford Burnham Prebys Medical Discovery Institute
- Applicant Address: US CA La Jolla
- Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Current Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Current Assignee Address: US CA La Jolla
- Agency: Wilson Sonsini Goodrich & Rosati
- International Application: PCT/US2014/054116 WO 20140904
- International Announcement: WO2015/035063 WO 20150312
- Main IPC: A61K31/7088
- IPC: A61K31/7088 ; A61K31/7105 ; A61K38/20 ; C12N15/113 ; C07K16/28 ; G01N33/50 ; A61K45/06 ; A61K31/00 ; C07K14/54 ; A61K39/00
Abstract:
The present invention relate to the discovery that BTLA, IL-7 and RORγt modulate the activity and expression of γδT cells. Specifically, the present invention provides methods of modulating γδT cell homeostasis and function by regulating expression of BTLA. The present invention further provides agents which modulate the activity and expression of BTLA, RORyt and IL-7 and methods for screening of such agents. The present invention also provides methods for treating autoimmune or inflammatory diseases using modulators of BTLA, RORyt and IL-7.
Public/Granted literature
- US20160194403A1 MODULATION OF GAMMA DELTA T CELLS Public/Granted day:2016-07-07
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