Invention Grant
- Patent Title: Prevention of disulfide bond reduction during recombinant production of polypeptides
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Application No.: US16240592Application Date: 2019-01-04
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Publication No.: US10759866B2Publication Date: 2020-09-01
- Inventor: Yung-Hsiang Kao , Michael W. Laird , Melody Trexler Schmidt , Rita L. Wong , Daniel P. Hewitt
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Morrison & Foerster LLP
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K1/14 ; A61K39/395
Abstract:
Provide herein are methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.
Public/Granted literature
- US20190135935A1 PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES Public/Granted day:2019-05-09
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