Invention Grant
- Patent Title: Antibody variants and uses thereof
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Application No.: US14130543Application Date: 2012-07-06
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Publication No.: US10759867B2Publication Date: 2020-09-01
- Inventor: Paul Parren , Frank Beurskens , Rob N. De Jong , Aran Frank Labrijn , Janine Schuurman
- Applicant: Paul Parren , Frank Beurskens , Rob N. De Jong , Aran Frank Labrijn , Janine Schuurman
- Applicant Address: NL Utrecht
- Assignee: GENMAB B.V.
- Current Assignee: GENMAB B.V.
- Current Assignee Address: NL Utrecht
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Christopher L. Frank
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@5435a152 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@13546990
- International Application: PCT/EP2012/063339 WO 20120706
- International Announcement: WO2013/004842 WO 20130110
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C12N15/00 ; C07K16/00 ; C07K16/28 ; C07K16/36 ; A61K39/00
Abstract:
Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC-response.
Public/Granted literature
- US20140242075A1 ANTIBODY VARIANTS AND USES THEREOF Public/Granted day:2014-08-28
Information query
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