Invention Grant
- Patent Title: Conditionally immortalized long-term stem cells and methods of making and using such cells
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Application No.: US16042904Application Date: 2018-07-23
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Publication No.: US10760055B2Publication Date: 2020-09-01
- Inventor: John C. Cambier , Yosef Refaeli , Sara Ann Johnson , Brian Curtis Turner
- Applicant: NATIONAL JEWISH HEALTH , THE REGENTS OF THE UNIVERSITY OF COLORADO
- Applicant Address: US CO Denver US CO Boulder
- Assignee: NATIONAL JEWISH HEALTH,THE REGENTS OF THE UNIVERSITY OF COLORADO
- Current Assignee: NATIONAL JEWISH HEALTH,THE REGENTS OF THE UNIVERSITY OF COLORADO
- Current Assignee Address: US CO Denver US CO Boulder
- Agency: Foley & Lardner LLP
- Main IPC: C07K14/005
- IPC: C07K14/005 ; C12N5/0789 ; C07K14/47 ; C07K14/82 ; C12N5/0781 ; C12N5/0783 ; C12N15/62
Abstract:
Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.
Public/Granted literature
- US20190024051A1 CONDITIONALLY IMMORTALIZED LONG-TERM STEM CELLS AND METHODS OF MAKING AND USING SUCH CELLS Public/Granted day:2019-01-24
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