Invention Grant
- Patent Title: Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
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Application No.: US16225909Application Date: 2018-12-19
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Publication No.: US10760078B2Publication Date: 2020-09-01
- Inventor: Gunnar J. Hanson , Alexander Charles Rudolph , Bao Zhong Cai , Ming Zhou , Dwight D. Weller
- Applicant: Sarepta Therapeutics, Inc.
- Applicant Address: US MA Cambridge
- Assignee: SAREPTA THERAPEUTICS, INC.
- Current Assignee: SAREPTA THERAPEUTICS, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Lathrop GPM LLP
- Agent Brian C. Trinque; Andrew R. Ehle
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07F9/59 ; C07F9/572 ; C07F9/6558 ; C07F9/6561 ; C07F9/6584 ; C07H21/00 ; A61K31/496 ; A61K31/5377 ; C07D265/30 ; C07D295/108 ; C07F9/22 ; C07F9/26 ; C07F9/6544
Abstract:
Oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.
Public/Granted literature
- US20190218551A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS Public/Granted day:2019-07-18
Information query
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