Various techniques manage a storage system. Such techniques involve, in response to receiving an Input/Output (I/O) request for a first slice of a logic storage unit in a storage system, obtaining a first bitmap with respect to the logic storage unit, the logic storage unit being divided into a plurality of slices including the first slice, and one bit in the first bitmap indicating whether a cache function is enabled for a respective one of the plurality of slices. The techniques further involve determining, based on the first bitmap, whether the cache function is enabled for the first slice. Moreover, the techniques further involve, in response to determining that the cache function is enabled for the first slice, processing the I/O request at least with a cache in the storage system. Such techniques can control the use of cache in the storage system in a finer granularity.