Methods, systems, can computer program products for optimizing statistical method of computing output yields are provided. Aspects include determining a target criteria of a system for statistical analysis, based on the target criteria, determining a statistical analysis algorithm for the simulation, determining a block size for a plurality of statistical samples of the system for a parallelization of the statistical analysis algorithm, generating the plurality of statistical samples of the system, simulating the plurality of statistical samples of the system to determine one or more output yields, calculating a confidence interval for each of the one or more output yields, wherein the confidence interval comprises a lower bound, comparing the lower bound to a threshold standard deviation of a probability density function, and adjusting the block size for the plurality of statistical samples based on determining that the lower bound is less than the threshold standard deviation.