An irradiator apparatus and system that utilizes a single radiation source, such as X-rays, to irradiate product samples, such as blood, blood products, bone materials, or live laboratory animals, such as mice. The irradiator apparatus and system incorporates a radiation reflector having a moveable reflector portion, and a moving mechanism to allow product container rotation and orientation. In addition, a radiation filter is associated with the single radiation source, such as an X-ray source, to allow optimal dose distribution throughout the irradiated sample and compensate for beam profile asymmetry.