Methods and systems of identifying and remediating at-risk resources in a computing environment are provided. A method includes periodically determining respective infrastructure topologies of a computing environment that changes over time, wherein the determining is performed by a computer system communicating with the computing environment. The method also includes: identifying, by the computer system, an intrusion event in the computing environment; determining, by the computer system, at-risk resources in the computing environment based on the determined intrusion event and a corresponding one of the infrastructure topologies; and performing, by the computer system, remediation action for the at-risk resources.