Disclosed are various embodiments for a framework for time-associated data stream storage, processing, and replication. A plurality of streams of time-associated data are received from a plurality of sources via a network using an application-layer protocol. Each of the plurality of streams is divided into a plurality of fragments. An acknowledgement is sent to each of the plurality of sources for each of the plurality of fragments via the network using the application-layer protocol. Processing is performed on each of the plurality of fragments for individual ones of the plurality of streams. An action is implemented relative to a respective fragment based at least in part on a result of the processing.