Systems and methods for dynamically selecting and adjusting energy detection thresholds (EDTs) in uncoordinated radio nodes deploying Listen Before Talk to improve throughput on shared spectrum are disclosed. The uncoordinated radio nodes dynamically adjust an EDT to avoid harmful collisions with neighboring radio nodes or otherwise improve throughput over shared spectrum. A radio node can detect a collision or radio frequency (RF) interference from a neighboring radio node. Once the collision or RF interference is detected, the EDT of the radio node is dynamically adjusted. In some cases, the collision or RF interference can be avoided by calculating a throughput of the radio node while operating on each of a plurality of EDTs and selecting the EDT predicted to result in a higher throughput. In other cases, the EDT may be dynamically adjusted based on an iterative approach which incorporates measurements of the neighboring radio node.