Invention Grant
- Patent Title: Composition containing monoacetyldiglyceride compound as active ingredient for preventing or treating chronic obstructive pulmonary disease
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Application No.: US15857933Application Date: 2017-12-29
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Publication No.: US10765655B2Publication Date: 2020-09-08
- Inventor: Sei-Ryang Oh , Kyung Seop Ahn , Su Ui Lee , In Sik Shin , Ok-Kyoung Kwon , Seung Hyung Kim , Chan Mi Chun , Tae-Suk Lee , Yong-Hae Han , Ki Young Sohn , JongKoo Kang , Hye Kyung Kim
- Applicant: ENZYCHEM LIFESCIENCES CORPORATION , KOREA RESEARCH INSTITUTE OF BIO SCIENCE AND BIOTECHNOLOGY
- Applicant Address: KR Daejeon KR Daejeon
- Assignee: Enzychem Lifesciences Corporation,Korea Research Institute of BioScience and Biotechnology
- Current Assignee: Enzychem Lifesciences Corporation,Korea Research Institute of BioScience and Biotechnology
- Current Assignee Address: KR Daejeon KR Daejeon
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Peter F. Corless
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@3ed8152a
- Main IPC: A61K31/231
- IPC: A61K31/231

Abstract:
The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-α, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases.
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