Invention Grant
- Patent Title: Mutated immunoglobulin-binding protein having increased alkaline tolerance
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Application No.: US16240074Application Date: 2019-01-04
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Publication No.: US10766933B2Publication Date: 2020-09-08
- Inventor: Yong Chul Shin , Zhe Piao , Su-Lim Choi , Yang Ho Jo , So-Young Park , Dae Beom Kwon
- Applicant: Amicogen, Inc.
- Applicant Address: KR Gyeongsangnam-do
- Assignee: Amicogen, Inc.
- Current Assignee: Amicogen, Inc.
- Current Assignee Address: KR Gyeongsangnam-do
- Agency: Banner & Witcoff, Ltd.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@68768b8d
- Main IPC: C07K14/31
- IPC: C07K14/31 ; B01D15/38 ; C07K1/12
Abstract:
The present invention relates to a mutated immunoglobulin-binding protein having increased alkaline tolerance and, more specifically, to an immunoglobulin-binding protein in which, with respect to the A-domain of Staphylococcal protein A, or a functional variant thereof, an amino acid at a specific site is mutated and thereby exhibits an increased chemical stability at an alkaline pH value in comparison to a parental molecule. The present invention can provide an antibody-purifying immunoglobulin-binding protein ligand and matrix which have enhanced alkaline tolerance and accordingly enhanced stability in multiple times of alkaline cleaning.
Public/Granted literature
- US20190202871A1 Mutated Immunoglobulin-Binding Protein Having Increased Alkaline Tolerance Public/Granted day:2019-07-04
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