Invention Grant
- Patent Title: Binding molecules for BCMA and CD3
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Application No.: US14358511Application Date: 2012-11-15
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Publication No.: US10766969B2Publication Date: 2020-09-08
- Inventor: Peter Kufer , Tobias Raum , Patrick Hoffmann , Roman Kischel , Ralf Lutterbuese , Doris Rau , Paul Adam , Eric Borges , Barbara Hebeis , Susanne Hipp
- Applicant: Amgen Research (Munich) GmbH , Boehringer Ingelheim International GmbH
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agency: Kagan Binder, PLLC
- International Application: PCT/EP2012/072699 WO 20121115
- International Announcement: WO2013/072406 WO 20130523
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/46 ; A61K39/395 ; C07K14/705 ; A61K39/00

Abstract:
The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster3 of BCMA, and the second binding domain is capable of binding to the Tcell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
Public/Granted literature
- US20150023967A1 BINDING MOLECULES FOR BCMA AND CD3 Public/Granted day:2015-01-22
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