Example aspects of an over-pressure protection system and a method for using an over-pressure protection system are disclosed. The over-pressure protection system can comprise a main body comprising a main body housing, the main body housing defining a main body chamber; an incompressible fluid received in the main body chamber, the fluid defining a fluid pressure; a pressure sensor for measuring the fluid pressure of the incompressible fluid, the pressure sensor configurable an activated mode and a deactivated mode; a first barrier movable between a first position and a second position; wherein the over-pressure protection system is configurable an under-pressure configuration, wherein the pressure of the incompressible fluid is below a threshold pressure, and an over-pressure configuration, wherein the pressure of the incompressible fluid is equal to or above the threshold pressure; and a control system configuring the pressure sensor in the deactivated mode in the over-pressure configuration