Systems, methods, and non-transitory computer readable media may be configured to facilitate prioritization of vehicle navigation. One or more vehicles in an environment of a priority vehicle may be identified. Priorities of the vehicle(s) and the priority vehicle may be determined. A desired navigation of the priority vehicle in the environment may be determined based on the priorities of the vehicle(s) and the priority vehicle. An instruction may be provided to at least one of the vehicle(s) based on the desired navigation of the priority vehicle in the environment. The instruction may characterize one or more maneuvers to be performed by the at least one of the vehicle(s) to facilitate the desired navigation of the priority vehicle.