A method and a device for driving a display panel are provided by embodiments of the present application. The method includes: outputting an initial scanning signal including two pulse signals; pre-charging an x-th row of pixel drive cells when the x-th row of pixel drive cells receive a first pulse signal; and charging the x-th row of pixel drive cells when the x-th row of pixel drive cells receive a second pulse signal, writing data into the x-th row of pixel drive cells, and meanwhile, pre-charging an x+4m-th row of pixel drive cells.