The present application provides a fan-out semiconductor packaging structure with an antenna module and a method making the same. The fan-out semiconductor packaging structure with the antenna module comprises: a semiconductor chip; a plastic packaging material layer enclosing a periphery of the semiconductor chip; a filling structure disposed in the plastic packaging material layer and disposed on the periphery of the semiconductor chip, a loss caused by the filling structure to an antenna signal is smaller than a loss caused by the plastic packaging material layer to an antenna signal; an antenna module disposed on the first surface of the plastic packaging material layer, an orthographic projection of the antenna module on the filling structure is disposed on the filling structure; a redistribution layer disposed on the second surface of the plastic packaging material layer; and a solder bump disposed on a surface of the redistribution layer.