In some examples, crosstalk cancellation for speaker-based spatial rendering may include perceptually smoothing head-related transfer functions (HRTFs) corresponding to ipsilateral and contralateral transfer paths of sound emitted from first and second speakers to corresponding first and second destinations. The crosstalk cancellation may further include inserting an inter-aural time difference in the perceptually smoothed HRTFs corresponding to the contralateral transfer paths. A crosstalk canceller may be generated by inverting the perceptually smoothed HRTFs corresponding to the ipsilateral transfer paths and the perceptually smoothed HRTFs corresponding to the contralateral transfer paths including the inserted inter-aural time difference.