A power control method, a network-side device, and a user equipment (UE), where the power control method includes obtaining, by a network-side device, at least two target subframe sets, and configuring, by the network-side device, power control parameters respectively corresponding to different target subframe sets on a flexible time-frequency resource for UE such that the UE transmits data in subframes in the target subframe sets according to the power control parameters, where the flexible time-frequency resource includes a time domain resource or a frequency domain resource whose transmission direction is configurable.