Invention Grant
- Patent Title: Compositions and methods of increasing longevity or treating cellular stress
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Application No.: US15543367Application Date: 2016-01-13
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Publication No.: US10772938B2Publication Date: 2020-09-15
- Inventor: Laura E. Niklason , Xiangru Xu , Hong Qian
- Applicant: YALE UNIVERSITY
- Applicant Address: US CT New Haven
- Assignee: Yale University
- Current Assignee: Yale University
- Current Assignee Address: US CT New Haven
- Agency: Saul Ewing Arnstein & Lehr LLP
- Agent Kathryn Doyle
- International Application: PCT/US2016/013220 WO 20160113
- International Announcement: WO2016/115233 WO 20160721
- Main IPC: A61K38/45
- IPC: A61K38/45 ; A61K31/7088 ; C12N15/113 ; C12N9/12 ; A61K38/17
Abstract:
The present invention includes methods and compositions for increasing longevity of a cell and increasing cellular resistance to stress. In certain embodiments, the invention includes a method to induce gene expression of a homolog of Pachytene Checkpoint 2 (pch-2) or bmk-1 gene. The present invention also includes methods to treat oxidative stress or induce cellular death or apoptosis by administering a composition comprising a modulator of pch-2 or bmk-1 homolog gene expression.
Public/Granted literature
- US20180008679A1 COMPOSITIONS AND METHODS OF INCREASING LONGEVITY OR TREATING CELLULAR STRESS Public/Granted day:2018-01-11
Information query
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