Invention Grant
- Patent Title: Modified Polynucleotides for the production of biologics and proteins associated with human disease
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Application No.: US15790246Application Date: 2017-10-23
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Publication No.: US10772975B2Publication Date: 2020-09-15
- Inventor: Stephane Bancel , Tirtha Chakraborty , Antonin De Fougerolles , Sayda M. Elbashir , Matthias John , Atanu Roy , Susan Whoriskey , Kristy M. Wood , Paul Hatala , Jason P. Schrum , Kenechi Ejebe , Jeff Lynn Ellsworth , Justin Guild
- Applicant: ModernaTX, Inc.
- Applicant Address: US MA Cambridge
- Assignee: ModernaTX, Inc.
- Current Assignee: ModernaTX, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Clark & Elbing LLP
- Main IPC: C07K14/535
- IPC: C07K14/535 ; A61K38/17 ; A61K48/00 ; C12N15/85 ; C07K14/47 ; C07K14/62 ; A61K31/7115 ; C12N9/88 ; A61K9/127 ; C12N15/11 ; C07K14/705 ; C07K14/505 ; C12N9/64 ; C12N9/10 ; C12N9/00 ; C12N9/42 ; C12N15/87 ; C12P13/04 ; A61K38/45 ; C07K14/005 ; C12N9/16 ; C12N9/24 ; C12N15/52 ; C07K14/435 ; C12P21/00 ; C07K14/485 ; C07H21/02 ; C07K14/475 ; C07K14/495 ; C07K14/525 ; C07K14/54 ; C07K14/56 ; C07K14/61 ; C07K14/745 ; C07K16/28 ; C07K16/40 ; C12N9/02 ; C12N9/12 ; C12N9/68 ; A61K47/54 ; A61K9/14 ; A61K9/51 ; A61K38/18 ; A61K38/19 ; A61K38/21 ; A61K38/48 ; C07K14/515 ; C07K16/00 ; A61K31/7088 ; A61K47/10 ; A61K38/00
Abstract:
The invention relates to a pharmaceutical composition including a plurality of lipid nanoparticles having a mean particle size of between 80 nm and 160 nm and containing an mRNA encoding a polypeptide. The lipid nanoparticles include a cationic lipid, a neutral lipid, a cholesterol, and a PEG lipid. The mRNA contains a 5′-cap, 5′-UTR, a 3′-UTR, and a poly-A region with at least 100 nucleotides.
Public/Granted literature
- US20180311381A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF BIOLOGICS AND PROTEINS ASSOCIATED WITH HUMAN DISEASE Public/Granted day:2018-11-01
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