Medical appliance securement device and method of using the same. In one embodiment, the medical appliance securement device includes an anchor. The anchor includes a top surface and a bottom surface. The bottom surface is adhesive. The device also includes a pair of foam blocks secured to the top surface of the anchor and arranged to define a channel for snugly receiving a medical appliance. The device also includes a retaining tab having a first end fixed to the anchor and a second end free to move relative to said anchor and appropriately spaced from the first end of the retaining tab to be wrapped around at least a portion of a medical appliance in the channel. The device also includes a first set of complementary fasteners disposed on the anchor and the retaining tab for detachably coupling the free end of the retaining tab to the anchor.