Invention Grant
- Patent Title: 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
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Application No.: US16117674Application Date: 2018-08-30
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Publication No.: US10774065B2Publication Date: 2020-09-15
- Inventor: Christine Hiu-Tung Chen , Zhuoliang Chen , Jorge Garcia Fortanet , Denise Grunenfelder , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Travis Matthew Stams , Sarah Williams
- Applicant: Christine Hiu-Tung Chen , Zhuoliang Chen , Jorge Garcia Fortanet , Denise Grunenfelder , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Travis Matthew Stams , Sarah Williams
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Scott W. Reid
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D239/48 ; C07D241/26 ; C07D249/14 ; C07D401/14 ; C07D403/04 ; C07D409/14 ; C07D471/04 ; C07D487/04
Abstract:
The present invention relates to compounds of formula I: in which m, Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a and R5b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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