Invention Grant
- Patent Title: Boron compounds as inhibitors of lipoxygenase and the lipoxygenase pathway, and preparation and use thereof
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Application No.: US15770477Application Date: 2016-10-21
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Publication No.: US10774097B2Publication Date: 2020-09-15
- Inventor: Evamarie Hey-Hawkins , Robert Kuhnert
- Applicant: UNIVERSITÄT LEIPZIG
- Applicant Address: DE Leipzig
- Assignee: UNIVERSITÄT LEIPZIG
- Current Assignee: UNIVERSITÄT LEIPZIG
- Current Assignee Address: DE Leipzig
- Agency: FisherBroyles, LLP
- Agent Andrew K. Gonsalves, Esq.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@4d07a9d7
- International Application: PCT/EP2016/075419 WO 20161021
- International Announcement: WO2017/068145 WO 20170427
- Main IPC: C07F5/02
- IPC: C07F5/02 ; A61P25/28 ; A61P37/08

Abstract:
The invention relates to chemical compound of the general structure [A-R3—X—R4] where A=[R1-R2] or [R1] R1=aryl, heteroaryl R2=alkyl, aryl, heteroaryl, carbonyl, thiocarbonyl, alkyl ester, alkyl thioester R3=O, S, NH X=closo- or nido-boron cluster R4= where Z=OH, SH, NH2 where R5 is selected from H, alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and R6 is selected from alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and where R3 and R4 are in meta or para positions to one another, to a process for preparation thereof and to the use thereof, especially in medicine, for example in the inhibition of lipoxygenase.
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