Invention Grant
- Patent Title: Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
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Application No.: US15374539Application Date: 2016-12-09
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Publication No.: US10774124B2Publication Date: 2020-09-15
- Inventor: Richard T. Lee , Vincent Segers
- Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- Applicant Address: US MA Boston
- Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- Current Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Ravinderjit Braich
- Main IPC: C07K14/52
- IPC: C07K14/52 ; C12N5/077 ; A61K38/00
Abstract:
The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-1 to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.
Public/Granted literature
- US20170101451A1 PROTEASE RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN THE REPAIR OF TISSUE DAMAGE Public/Granted day:2017-04-13
Information query
