Invention Grant
- Patent Title: Reduced size self-delivering RNAI compounds
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Application No.: US14866681Application Date: 2015-09-25
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Publication No.: US10774330B2Publication Date: 2020-09-15
- Inventor: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
- Applicant: Phio Pharmaceuticals Corp.
- Applicant Address: US MA Malborough
- Assignee: Phio Pharmaceuticals Corp.
- Current Assignee: Phio Pharmaceuticals Corp.
- Current Assignee Address: US MA Malborough
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07H21/04 ; A61K31/713 ; C12N15/11
Abstract:
The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing.
Public/Granted literature
- US20160244765A1 REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS Public/Granted day:2016-08-25
Information query
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