Invention Grant
- Patent Title: Stationary phase for detecting a specific analyte in a mixture, uses thereof and method for detecting a specific analyte in a mixture
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Application No.: US16348013Application Date: 2017-11-07
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Publication No.: US10775374B2Publication Date: 2020-09-15
- Inventor: Ralph Sperling , Ralf Himmelreich , Tobias Schunck , Raphael Thiermann
- Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
- Applicant Address: DE Munich
- Assignee: Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V.
- Current Assignee: Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V.
- Current Assignee Address: DE Munich
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@4689a475
- International Application: PCT/EP2017/078492 WO 20171107
- International Announcement: WO2018/087093 WO 20180517
- Main IPC: G01N33/558
- IPC: G01N33/558

Abstract:
The invention presents a stationary phase for detecting at least one specific analyte in a mixture. The stationary phase includes a solid phase divided into a plurality of zones for transporting liquid by capillary force. The solid phase includes at least one first zone suitable for receiving a liquid sample, a second zone on which a receptor is immobilized, wherein the receptor is suitable for binding to a ligand, and a third zone on which quantum dots are immobilized, function as FRET donors and are linked to at least one suitable FRET acceptor via at least one oligonucleotide linker. The stationary phase exhibits improved detection sensitivity and allows simultaneous and multiparametric detection of a wide variety of analytes. The invention proposes uses of the stationary phase and also presents a method for detecting at least one specific analyte in a mixture.
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