Technologies for context aware graphical user interfaces for mobile compute devices include a mobile compute device that includes a touchscreen display, a wireless signal sensor to receive a wireless signal transmitted by a wearable device, a context determination module, and a graphical user interface manager module. The context determination module is to measure a strength of the wireless signal and identify which hand of the user is presently used to hold the mobile compute device based on the measured strength of the wireless signal. The graphical user interface manager module is to configure a graphical user interface displayed on the touchscreen display based on the identification of the hand of the user presently used to hold the mobile compute device.