The present application relates to method and device for determining image similarity that includes: dividing a target image into multiple regions based on positions of pixels relative to a reference point in the target image, and dividing a reference image into multiple regions based on positions of pixels relative to a reference point in the reference image; determining, based on feature points in the target image and feature points in the reference image as well as the regions obtained by dividing the target image and the regions obtained by dividing the reference image, similarity between a distribution of the feature points in the target image and a distribution of the feature points in the reference image. According to the method of the present application, the similarity is described more reasonably.