Systems and methods are described for monitoring, detecting, and initiating a response to an environmental anomaly within a shipping container of packages involves sensor-based ID nodes, a command node and an external transceiver on a transit vehicle. Each ID node generates and broadcasts sensor data on environmental conditions proximate the respective ID node within the shipping container. The command node detects the sensor data from each ID node and compares it with locally maintained context data (an environmental threshold condition) for that ID node to detect the environmental anomaly when sensor data exceeds a respective threshold condition. The command node then generates a layered alert notification related to the environmental anomaly identifying a targeted mediation recipient and targeted mediation action, and establishing a mediation response priority. The command node initiates a mediation response related to the targeted mediation action by transmitting the layered alert notification transmitted to the external transceiver.