The disclosure relates to a driving method and a driving device for a display panel and a display device, wherein the display panel includes a plurality of first pixel units and a plurality of second pixel units which are disposed adjacently. The driving method includes dividing a plurality of pixel units of the display panel into a plurality of pixel unit groups; driving subpixels in first pixel units and subpixels in second pixel units by using drive voltages of different voltage levels; driving the subpixels arranged in the same line in every two adjacent pixel unit groups by using the drive voltages of opposite polarities; and driving every continuously arranged four lines of pixel units in the same one of the pixel unit groups by using the drive voltages of different polarities.