Invention Grant
- Patent Title: Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators
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Application No.: US16301935Application Date: 2017-05-11
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Publication No.: US10780092B2Publication Date: 2020-09-22
- Inventor: Alan Whitehead , Olga Ornoski , Subharekha Raghavan , Raphaelle Berger , Joie Garfunkle , Zhiqiang Yang , Gang Ji , Falong Jiang , Jianmin Fu
- Applicant: Merck Sharp & Dohme Corp. , Alan Whitehead , Olga Ornoski , Subharekha Raghavan , Raphaelle Berger , Joie Garfunkle , Zhiqiang Yang , Gang Ji , Falong Jiang , Jianmin Fu
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Eric Meade; John C. Todaro
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@7ae8b42d
- International Application: PCT/US2017/032060 WO 20170511
- International Announcement: WO2017/200825 WO 20171123
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D519/00 ; A61K31/519 ; A61P9/12

Abstract:
The invention provides certain fused pyrazine compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, R1, R3, R4a, R5a, R5b, R6, and the subscript t are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases or disorders which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and disorders and for preparing pharmaceuticals for this purpose.
Public/Granted literature
- US20190307753A1 FUSED PYRAZINE DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE STIMULATORS Public/Granted day:2019-10-10
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