Invention Grant
- Patent Title: Methods and compositions for cellular immunotherapy
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Application No.: US15989098Application Date: 2018-05-24
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Publication No.: US10780119B2Publication Date: 2020-09-22
- Inventor: Kevin R. Webster , Rajesh Sharma , Gary Chiang
- Applicant: eFFECTOR Therapeutics, Inc.
- Applicant Address: US CA San Diego
- Assignee: eFFECTOR Therapeutics Inc.
- Current Assignee: eFFECTOR Therapeutics Inc.
- Current Assignee Address: US CA San Diego
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04 ; A61K35/17 ; C07K14/74 ; A61P35/00 ; C07K14/725 ; C07K14/73 ; C07K14/16 ; C07K14/705 ; C12N5/0783 ; C07D471/04 ; C07D487/04 ; C07D495/20 ; C07D491/20 ; C07D471/20 ; A61K31/501 ; A61K45/06
Abstract:
The present disclosure relates to genetically modified T cells comprising a transgene encoding an engineered antigen specific receptor, wherein expression of an endogenous gene selected from MNK1, MNK2, or both are inhibited in the genetically modified T cell in order to enhance central memory T cell subsets in cellular immunotherapy compositions.
Public/Granted literature
- US20180353545A1 METHODS AND COMPOSITIONS FOR CELLULAR IMMUNOTHERAPY Public/Granted day:2018-12-13
Information query
