- Patent Title: Compositions and methods of use for (pro)renin receptor antagonists
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Application No.: US15501159Application Date: 2015-07-31
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Publication No.: US10780143B2Publication Date: 2020-09-22
- Inventor: Yumei Feng Earley , Tianxin Yang
- Applicant: University of Utah Research Foundation
- Applicant Address: US UT Salt Lake City
- Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
- Current Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
- Current Assignee Address: US UT Salt Lake City
- Agency: Ballard Spahr LLP
- International Application: PCT/US2015/043085 WO 20150731
- International Announcement: WO2016/019226 WO 20160204
- Main IPC: A61K38/10
- IPC: A61K38/10 ; C07K7/08 ; A61P9/12 ; A61P17/02 ; A61P31/00 ; A61P13/12
Abstract:
Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin receptor (PRR) antagonist. In some instances the PRR antagonist is a polypeptide. The PRR antagonist can be a polypeptide having at least 70% identity to the amino acid sequence set forth in SEQ ID NO:2. Also disclosed are methods of decreasing proteinuria and methods of promoting wound healing by administering a PRR antagonist.
Public/Granted literature
- US20180125922A1 COMPOSITIONS AND METHODS OF USE FOR (PRO)RENIN RECEPTOR ANTAGONISTS Public/Granted day:2018-05-10
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