The present invention provides a system and method for quickly removing and installing a filament tube and nozzle in an FFF extrusion system. The system utilizes a primary manifold that includes a cooling block, a heating block and a quick-change mechanism. This primary manifold is adapted to mate a filament tube/nozzle assembly. The quick-change mechanism, which in a particular embodiment utilizes a recessed biased-bearing arrangement, enables the filament/nozzle assembly to be removed and inserted without the use of any tools, and without causing any significant downtime for the FFF extrusion system. Once removed, the filament tube/nozzle assembly can be refurbished by a technician, trained so as not to over torque the tube/nozzle threaded interface. This refurbishment (typically consisting of a cleaning and the installation of a new nozzle) could be accomplished “off-line”, without any impact on the continued use of FFF extrusion system.