Invention Grant
- Patent Title: N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
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Application No.: US15526421Application Date: 2015-11-26
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Publication No.: US10781181B2Publication Date: 2020-09-22
- Inventor: David Michael Evans , Rebecca Louise Davie , Hannah Joy Edwards , Simon Teanby Hodgson
- Applicant: Kalvista Pharmaceuticals Limited
- Applicant Address: GB Porton Down, Wiltshire
- Assignee: KALVISTA PHARMACEUTICALS LIMITED
- Current Assignee: KALVISTA PHARMACEUTICALS LIMITED
- Current Assignee Address: GB Porton Down, Wiltshire
- Agency: BakerHostetler
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@411df87a
- International Application: PCT/GB2015/053613 WO 20151126
- International Announcement: WO2016/083818 WO 20160602
- Main IPC: C07D401/10
- IPC: C07D401/10 ; C07D231/14 ; C07D231/38 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D401/06 ; C07D403/06 ; C07D409/14 ; C07D413/06 ; C07D413/10 ; C07D417/06 ; C07D417/10 ; C07D417/14 ; A61K31/415 ; A61K31/501 ; A61K31/416 ; A61K31/4439 ; A61K31/4709 ; A61K31/506 ; C07D403/10
Abstract:
The present invention provides compounds of formula (I): (I) compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, U, D, E, W, X, Y and Z are as defined herein.
Public/Granted literature
- US20170305863A1 N-((HET) ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS Public/Granted day:2017-10-26
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