- Patent Title: Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
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Application No.: US16344721Application Date: 2017-10-23
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Publication No.: US10781182B2Publication Date: 2020-09-22
- Inventor: Cristiano Ruch Werneck Guimarães , Hatylas Felype Zaneti De Azevedo , Alessandra Mascarello , Renata Watanabe Da Costa , Valter Freire Torres Russo , Elisa Mannochio De Souza Russo
- Applicant: ACHÉ LABORATÓRIOS FARMACÊUTICOS S.A.
- Applicant Address: BR Guarulhos
- Assignee: ACHÉ LABORATÓRIOS FARMACÊUTICOS S.A.
- Current Assignee: ACHÉ LABORATÓRIOS FARMACÊUTICOS S.A.
- Current Assignee Address: BR Guarulhos
- Agency: Stites & Harbison, PLLC
- Agent B. Aaron Schulman, Esq.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@114db5a4
- International Application: PCT/BR2017/050320 WO 20171023
- International Announcement: WO2018/076090 WO 20180503
- Main IPC: C07D235/26
- IPC: C07D235/26 ; C07D235/28 ; C07D491/048 ; A61P25/24 ; A61P25/20 ; A61P25/22
Abstract:
The present invention relates to novel and inventive pharmacologically active benzimidazole derivative compounds, which surprisingly have high affinity for melatonin MT1 and MT2 receptors and low affinity for CYP450 complex enzymes, specially CYP1A2. The present invention also relates to novel and inventive routes of synthesis of these compounds, pharmaceutical compositions comprising the compounds and the use of these compounds in the treatment of individuals affected by psychiatric disorders and/or sleep disorders related to these receptors (specially depression, anxiety, circadian cycle disorders), in addition to process for producing the composition.
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