Invention Grant
- Patent Title: Small molecule inducers of reactive oxygen species and inhibitors of mitochondrial activity
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Application No.: US16083376Application Date: 2017-03-07
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Publication No.: US10781183B2Publication Date: 2020-09-22
- Inventor: Nouri Neamati , Mario Sechi
- Applicant: The Regents of the University of Michigan , UNIVERSITÀ DEGLI STUDI DI SASSARI
- Applicant Address: US MI Ann Arbor IT Sassari
- Assignee: The Regents of the University of Michigan,UNIVERSITA DEGLI STUDI DI SASSARI
- Current Assignee: The Regents of the University of Michigan,UNIVERSITA DEGLI STUDI DI SASSARI
- Current Assignee Address: US MI Ann Arbor IT Sassari
- Agency: Casimir Jones, SC
- Agent Robert A. Goetz
- International Application: PCT/US2017/021150 WO 20170307
- International Announcement: WO2017/155991 WO 20170914
- Main IPC: C07D239/74
- IPC: C07D239/74 ; A61P35/00 ; C07D401/12 ; C07D403/12 ; C07D405/12 ; C07D413/12 ; C07D417/12 ; C07D471/04 ; A61K31/5377 ; A61K45/06 ; A61K31/517
Abstract:
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazolinedione structure which function as reactive oxygen species (ROS) inducers and inhibitors of mitochondrial activity within cancer cells (e.g., pancreatic cancer cells), and their use as therapeutics for the treatment of cancer (e.g., pancreatic cancer) and other diseases.
Public/Granted literature
- US20190308942A1 SMALL MOLECULE INDUCERS OF REACTIVE OXYGEN SPECIES AND INHIBITORS OF MITOCHONDRIAL ACTIVITY Public/Granted day:2019-10-10
Information query
