Invention Grant
- Patent Title: EPHA2 t-cell epitope agonists and uses therefore
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Application No.: US16152242Application Date: 2018-10-04
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Publication No.: US10781240B2Publication Date: 2020-09-22
- Inventor: Walter J. Storkus , Michael S. Kinch
- Applicant: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- Applicant Address: US PA Pittsburgh
- Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- Current Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- Current Assignee Address: US PA Pittsburgh
- Agency: Baker Botts L.L.P.
- Main IPC: A61K38/17
- IPC: A61K38/17 ; C07K7/06 ; C07K7/08 ; C07K14/47 ; C07K14/705 ; G01N33/50 ; G01N33/569 ; A61K39/00
Abstract:
EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative derivatives thereof. The EphA2 T-cell epitopes are useful in an assay, such as an ELISPOT assay, that may be used to determine and/or quantify a patient's immune responsiveness to EphA2. The epitopes also are useful in methods of modulating a patient's immune reactivity to EphA2, which has substantial utility as a treatment for cancers that overexpress EphA2, such as renal cell carcinoma (RCC). The EphA2 epitopes also can be used to vaccinate a patient against EphA2, by in vivo or ex vivo methods.
Public/Granted literature
- US20190023756A1 EPHA2 T-CELL EPITOPE AGONISTS AND USES THEREFORE Public/Granted day:2019-01-24
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