Invention Grant
- Patent Title: PSMA and CD3 bispecific T cell engaging antibody constructs
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Application No.: US15422661Application Date: 2017-02-02
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Publication No.: US10781264B2Publication Date: 2020-09-22
- Inventor: Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
- Applicant: AMGEN RESEARCH (MUNICH) GMBH
- Applicant Address: DE Munich
- Assignee: AMGEN RESEARCH (MUNICH) GMBH
- Current Assignee: AMGEN RESEARCH (MUNICH) GMBH
- Current Assignee Address: DE Munich
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K16/30 ; C07K16/28

Abstract:
The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
Public/Granted literature
- US20170218079A1 PSMA and CD3 Bispecific T Cell Engaging Antibody Constructs Public/Granted day:2017-08-03
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