Methods and apparatus to optimize ramp rates in combined cycle power plants are disclosed herein. An example method disclosed herein includes predicting a first setpoint for a gas turbine in a combined cycle power plant over a prediction horizon and predicting a second setpoint for a steam generator over the prediction horizon. The example method includes identifying a first steam property of steam generated by the steam generator in the combined cycle power plant based on the second setpoint. The example method includes comparing the first steam property to a second steam property of steam associated with a steam turbine in the combined cycle power plant and dynamically adjusting at least one of the first setpoint or the second setpoint based on the comparison.