A metadata management method for a memory device includes generating a virtual address layer in a memory space of a non-volatile memory of the memory device; establishing a mapping table in the virtual address layer to store at least one metadata corresponding to at least one storing block, wherein the at least one storing block comprises at least one physical address and the at least one physical address is related to the memory space; when writing at least one datum to the memory device, writing the at least one datum to at least one memory block of the memory space according to the at least one physical address; and updating the at least one metadata of the at least one storing block when finishing writing the at least one datum.