An image sensor pixel may include a photodiode, a floating diffusion, and a transfer gate. Column readout circuitry coupled to the image sensor pixel via a column line. The column readout circuitry may include sample and hold circuitry, comparison circuitry, residual measurement and summation circuitry, counter circuitry, analog-to-digital conversion circuitry, and digital summation circuitry. Column readout circuitry is configured to perform readout operations on a pixel image signal generated for a single frame in one or more portions, thereby extending the dynamic range of the imaging system without modifying pixel structure to generate high-dynamic range images within the single frame.