Systems and methods of aligning a radio interface frame timing reference in a pool of Radio Equipment Controllers (RECs) are provided. In some embodiments, a method of operation of an REC includes computing a radio interface frame timing offset for a target REC relative to a reference time and 5 sending the radio interface frame timing offset to the target REC via an asynchronous communication network. According to some embodiments, this provides a substantially aligned radio interface frame timing reference in a pool of RECs. In some embodiments, the method also includes, prior to computing the radio interface frame timing offset, determining that the REC is a master REC. In some embodiments, determining that the REC is the master REC includes exchanging information indicative of at least one capability of each of the RECs and determining that the REC is the master REC based on the at least one capability.