Invention Grant
- Patent Title: Magnetic resonance imaging of poly-L-glutamate
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Application No.: US14781441Application Date: 2014-04-04
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Publication No.: US10791989B2Publication Date: 2020-10-06
- Inventor: Mohammad Haris , Anup Singh , Kejia Cai , Ravinder Reddy , Feliks Kogan , Ravi Prakash Reddy Nanga , Hari Hariharan
- Applicant: The Trustees of The University of Pennsylvania
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: BakerHostetler
- International Application: PCT/US2014/033003 WO 20140404
- International Announcement: WO2014/165775 WO 20141009
- Main IPC: A61B5/055
- IPC: A61B5/055 ; A61B5/00 ; G01R33/56 ; A61M5/00 ; A61B5/145 ; G01R33/46 ; G01R33/483
Abstract:
A non-invasive imaging approach using CEST and MRS may be used to monitor the cleavage of the poly-L-glutamate (PLG) backbone. The cleavage of PLG by cathespsin B can expose exchangeable —NH2 protons in the PLG that are then monitored non-invasively through CEST. The technique can provide direct information on malignant tissue and tumor aggressiveness, and can also be used to monitor treatment.
Public/Granted literature
- US20160041245A1 MAGNETIC RESONANCE IMAGING OF POLY-L-GLUTAMATE Public/Granted day:2016-02-11
Information query
