A system for automated simultaneous measurements of multiple parameters (mechanical, electrical and/or thermal) of biological tissues includes a base platform supporting a biochip holder module with a biochip integrated therein and an indenter for nano- and micro-scale indentation of a tissue. The biochip is formed with an array of micro-sensors, for example, electromechanical micro-sensors integrated on a substrate of the biochip. A temperature microsensor maybe additionally formed, for example, on the tip of the indenter to measure thermal characteristics of the tissue specimen heated by the micro-heater fabricated on the biochip.