Invention Grant
- Patent Title: Bicyclic peptide ligands specific for MT1-MMP
-
Application No.: US16838367Application Date: 2020-04-02
-
Publication No.: US10792368B1Publication Date: 2020-10-06
- Inventor: Daniel Paul Teufel , Catherine Lucy Stace , Silvia Pavan , Edward Walker , Leonardo Baldassarre
- Applicant: BicycleRD Limited
- Applicant Address: GB Cambridge
- Assignee: BicycleRD Limited
- Current Assignee: BicycleRD Limited
- Current Assignee Address: GB Cambridge
- Agency: Dechert LLP
- Agent Andrea L. C. Reid
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@4b18ffdf com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@c664ab1
- Main IPC: A61K47/64
- IPC: A61K47/64 ; C07K7/02 ; A61K51/04 ; A61K51/08 ; A61K47/54 ; A61K31/195 ; C07K7/08 ; A61P35/00

Abstract:
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
Public/Granted literature
- US20200289657A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP Public/Granted day:2020-09-17
Information query
IPC分类: