Methods, systems, and computer readable media for physiology parameter-invariant meal detection are disclosed. According to one system, the system includes at least one processor and a meal detection module implemented using the at least one processor. The meal detection module is configured to receive insulin intake information and blood glucose level information for a user, to detect a meal event using a physiology parameter-invariant meal detection algorithm, and after detecting the meal event, to perform at least one control action associated with insulin management.