A method of manufacturing a carbon fiber wheel rim is provided, including flowing steps of: preparing a core ring, including a core material which is disintegrable and annular; continuously obliquely winding at least one first dry carbon yarn around the core ring, to form a first semifinished rim; placing the first semifinished rim in a mold, and performing vacuuming, resin injection and thermoforming, to form a second semifinished rim; removing the second semifinished rim out of the mold, and disintegrating and removing the core material.